Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine |
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| Authors: | Canoa Pilar González-Moa María J Teijeira Marta Terán Carmen Uriarte Eugenio Pannecouque Christophe De Clercq Erik |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, Vigo, Spain. |
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| Abstract: | ![]()
Novel nucleoside analogues of structure 3-5 were synthesized starting from (+/-)-cis-2-amino-3-cyclopentenylmethanol (1). The chlorine derivative 3 inhibited both HIV-1 and HIV-2 replication in MT-4 cells with IC(50) values of 10.67 microM and of 13.79 microM, respectively. |
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