| 3-芳氧甲基/芳基-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性 |
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| 引用本文： | 史海健,王忠义,史好新. 3-芳氧甲基/芳基-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性[J]. 合成化学, 2000, 8(3): 226-230,255 |
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| 作者姓名： | 史海健 王忠义 史好新 |
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| 作者单位： | 安徽师范大学化学系,芜湖,241000;中国科技大学化学系,合肥,230026 |
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| 基金项目： | 安徽省自然科学基金,安徽省教育厅科研项目,,,, |
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| 摘 要： | 报道了3-芳氧甲基/芳基-4-氨基-5-巯基-1,2,4-三唑和芳酸在三氯氧磷作用下合成了16个标题化合物.其结构经元素分析、IR,1HNMR和MS确证.同时研究了反应条件.抗菌试验表明部分化合物具有较强的生物活性.
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| 关 键 词： | 三唑并噻二唑 芳酸 三氯氧磷 稠环化合物 合成 生物活性 |
| 修稿时间： | 1998-12-22 |
Synthesis of Derivatives of 3-Aryl/aryloxymethene-6-aryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and Theirs Biological Activities |
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| Abstract: | Sixteen title compounds had been prepared by the reaction of 3-aryl/aryloxymethene-4-amino-5-mercapto-1,2,4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride and their structures had been confirmed by elemental analysis, IR, 1H NMR and MS. These compounds were screened for their biological activities. Bacteriostatic tests indicated that some of them possess strong biological activities. The synthetic reaction conditions had also been investigated. |
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| Keywords: | Triazole Thiadiazole Arylcarboxylic acid Phosphorus oxychloride Biological activity Synthesis. |
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