| Catalytic hydrolysis of phosphate diester （BNPP） and plasmid DNA by mononuclear macrocyclic polyamine metal complexes |
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| 引用本文： | Qing Xiang Xiang,Li Qun Zhang,Xiao Qi Yu,Ru Gang Xie. Catalytic hydrolysis of phosphate diester （BNPP） and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. 中国化学快报, 2009, 20(5): 523-526. DOI: 10.1016/j.cclet.2009.01.001 |
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| 作者姓名： | Qing Xiang Xiang Li Qun Zhang Xiao Qi Yu Ru Gang Xie |
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| 作者单位： | a Department of Chemistry and Life Science, Leshan Teachers College, Leshan 614004, China;b Department of Chemistry, Sichuan University, Chengdu 610064, China |
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| 基金项目： | supported by the Science and Technology Department(No.04JY029-018);;Education Department of Sichuan Province(No.2006ZD049). |
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| 摘 要： | The activities of the catalytic hydrolysis of phosphate diester(BNPP)[bis(p-nitrophenyl)phosphate diester]and plasmid DNA (pUC18)by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper.The results showed that the highest activity in hydrolysis of BNPP was obtained with 1e-Zn(Ⅱ)complex(composed of lipophilic group)as catalyst.The hydrolysis rate enhancement is up to 3.64×10~4 fold.These metal complexes could effectively promote the cleavage of plasmid DNA(pUC18)at physiol...
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| 关 键 词： | Zn(Ⅱ) complex |
| 收稿时间： | 2008-10-07 |
Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes |
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| Qing Xiang Xiang,Li Qun Zhanga,Xiao Qi Yub,Ru Gang Xieb a. Catalytic hydrolysis of phosphate diester (BNPP) and plasmid DNA by mononuclear macrocyclic polyamine metal complexes[J]. Chinese Chemical Letters, 2009, 20(5): 523-526. DOI: 10.1016/j.cclet.2009.01.001 |
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| Authors: | Qing Xiang Xiang Li Qun Zhanga Xiao Qi Yub Ru Gang Xieb a |
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| Affiliation: | a Department of Chemistry and Life Science, Leshan Teachers College, Leshan 614004, China;b Department of Chemistry, Sichuan University, Chengdu 610064, China |
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| Abstract: | The activities of the catalytic hydrolysis of phosphate diester (BNPP) [bis(p-nitrophenyl)phosphate diester]and plasmid DNA (pUC 18) by mononuclear macrocyclic polyamine metal complexes have been investigated in this paper.The results showed that the highest activity in hydrolysis of BNPP was obtained with le-Zn(II) complex (composed of lipophilic group) as catalyst.The hydrolysis rate enhancement is up to 3.64 × 104 fold.These metal complexes could effectively promote the cleavage of plasmid DNA (pUC18) at physiological conditions. |
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| Keywords: | Catalytic hydrolysis Macrocyclic polyamine BNPP Plasmid DNA |
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