Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice |
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| Authors: | Terai Tadamasa Osakabe Kanehiro Katai Masaaki Sakaguchi Ken-Ichi Narama Isao Matsuura Tetsuro Katakawa Jun'ichi Tetsumi Tadahiro |
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| Institution: | Department of Applied Chemistry, Osaka Institute of Technology, Japan. tera@chem.oit.ac.jp |
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| Abstract: | Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II. |
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