Effect of Headgroups on Small‐Ion Permeability across Archaea‐Inspired Tetraether Lipid Membranes |
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| Authors: | Takaoki Koyanagi Dr Geoffray Leriche Alvin Yep David Onofrei Prof Gregory P Holland Prof Michael Mayer Prof Jerry Yang |
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| Institution: | 1. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA;2. Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA;3. Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland |
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| Abstract: | This paper examines the effects of four different polar headgroups on small‐ion membrane permeability from liposomes comprised of Archaea‐inspired glycerolmonoalkyl glycerol tetraether (GMGT) lipids. We found that the membrane‐leakage rate across GMGT lipid membranes varied by a factor of ≤1.6 as a function of headgroup structure. However, the leakage rates of small ions across membranes comprised of commercial bilayer‐forming 1‐palmitoyl‐2‐oleoyl‐sn‐glycerol (PO) lipids varied by as much as 32‐fold within the same series of headgroups. These results demonstrate that membrane leakage from GMGT lipids is less influenced by headgroup structure, making it possible to tailor the structure of the polar headgroups on GMGT lipids while retaining predictable leakage properties of membranes comprised of these tethered lipids. |
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| Keywords: | archaea biomimetic lipids membranes synthetic lipid |
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