2,3‐Diaryl‐3‐hydroxypropionic acid intermediates in the synthesis of threo forms of 1,2‐diaryl‐1,3‐propanediols |
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Authors: | Rolf Stomberg Vratislav Langer Knut Lundquist |
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Abstract: | Racemic threo‐3‐hydroxy‐2,3‐diphenylpropionic acid, C15H14O3, (I), crystallizes from ethyl acetate as a conglomerate of separate (+)‐ and (−)‐crystals. The geometries of (I) and its methyl ester are compared. Reduction of (I) gives threo‐1,2‐diphenyl‐1,3‐propanediol. The synthesis of threo forms of 1,2‐diaryl‐1,3‐propanediols via 2,3‐diaryl‐3‐hydroxypropionic acids is discussed. |
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