| Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives简 |
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| 基金项目： | the Outstanding Young Scholarship from the National Natural Science Foundation of China(No.30825043);NSFC(No.21172202);the Outstanding Scholar Foundation of Henan Province(No.094100510019)for financial support;supported by the National Key Basic Research Program of China(973 Program)(Nos.2010CB126105 and 2012CB724501);the National Key Technology Support Program during the 12th Five-Year Plan Period(Nos.2011BAE06B00,2011BAE06B01,2011BAE06B02,2011BAE06B03 and 2011BAE06B05) |
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| 摘 要： | Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.
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| 关 键 词： | 甲氧基丙烯酸酯类 嘧啶衍生物 杀螨活性 合成 生物活性 生物筛选 元素分析 生物测定 |
| 收稿时间： | 2013-05-15 |
| 修稿时间： | 2013-09-13 |
Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives |
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| Authors: | Bao-Shan Chai Chang-Ling Liu Hui-Chao Li Shao-Wu Liu Ying Xu Yu-Quan Song Jun-Biao Chang |
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| Institution: | a College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China;
b State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry Co., Ltd., Shenyang 110021, China |
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| Abstract: | Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus (Boisd.) at 0.625 mg L-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied. |
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| Keywords: | Strobilurin-pyrimidine Acaricidal activity Intermediate derivatization method Pyriminostrobin |
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