N-Protection of amines using pyridinium 2, 2, 2-trifluoroacetate ionic liquid as an efficient and reusable catalyst |
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Authors: | Somaye Karimian Hassan Tajik |
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Institution: | a Department of Chemistry, Persian Gulf University, Bushehr 75169, Iran;
b Department of Chemistry, University of Guilan, Rasht 41335/1914, Iran |
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Abstract: | A simple, green, and efficient method for the N-tert-butoxycarbonylation of amines by pyridinium 2,2,2- trifluoroacetate (Py]OTf]) as an efficient and reusable catalyst is reported. In general, electron donating groups on aryl group give rise to the higher yields than electron withdrawing groups. Clean reaction, short reaction times, high yields, reusability of catalyst, and easy preparation of it are some advantages of this work. |
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Keywords: | Ionic liquid Pyridinium 2 2 2-trifluoroacetate N-Boc protection Tert-butoxycarbonylation Amine |
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