| 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸的合成与表征 |
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| 引用本文： | 刘传飞,魏俊超,戴延凤.2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸的合成与表征[J].南昌大学学报(理科版),2011,35(3):1. |
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| 作者姓名： | 刘传飞 魏俊超 戴延凤 |
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| 作者单位： | 南昌大学化学系； |
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| 基金项目： | 江西省自然科学基金资助项目(2008GZH0043); 南昌大学科技基金资助项目(2009) |
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| 摘 要： | 以4-羟基苯甲醛为原料,经氰化、硫化、成环、Duff反应4步得到中间体2-(3-甲酰基-4-羟基苯基)-4-甲基-5-噻唑甲酸乙酯,后经醚化、氰化、水解得到Febuxostat,产物经IR1、H NMR1、3C NMR、MS和元素分析证实。
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| 关 键 词： | Febuxostat 4-羟基苯甲醛 抗痛风药 合成 |
Synthesis and characterization of 2-(3-cyano-4-isobutyl oxyphenyl)-4-methyl-5-thiazole carboxylic acid |
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| LIU Chuan-fei,WEI J un-chao,DAI Yan-feng.Synthesis and characterization of 2-(3-cyano-4-isobutyl oxyphenyl)-4-methyl-5-thiazole carboxylic acid[J].Journal of Nanchang University(Natural Science),2011,35(3):1. |
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| Authors: | LIU Chuan-fei WEI J un-chao DAI Yan-feng |
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| Institution: | LIU Chuan-fei,WEI Jun-chao,DAI Yan-feng(Department of Chemistry,Nanchang University,Nanchang 330031,China) |
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| Abstract: | Febuxostat was synthesized from 4-hydroxybenzaldehyde in this study Four-step reactions including cyanidation,thioformylation,cyclization,Duff reaction were performed generate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate,which was then processed by etherification,cyanidation and hydrolysis to form the final product,febuxostat.The structure of the target compounds were confirmed by IR,1H NMR,13C NMR,MS and elemental analysis. |
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| Keywords: | febuxostat antipodagrics 4-hydroxybenzaldehyde synthesis |
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