Synthesis and characterization of new galactosylated-based N2O-donors tridentate ligands |
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| Authors: | Lidiane C Castro Yasmim R Jaconiano Tereza C S Evangelista Sabrina B Ferreira |
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| Institution: | 1. Departamento de Química Inorganica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;2. Departamento de Química Organica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil |
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| Abstract: | The synthesis and characterization of three novel N2O-donor ligands containing the group 4-1-β-d-2,3,4,6-tetra-O-acetyl-galactosyl)]benzaldehyde are presented. The insertion of this group was designed to increase the absorption of the prodrug in tumor cells, and is part of an ongoing work in our group with tridentate ligands to develop potential cobalt(III) prodrugs. The synthetic route described here allowed the isolation of pure ligands with yields ranged 81–89%. Finally, compounds were characterized by IR, NMR and HRMS (ESI+). |
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| Keywords: | Cancer cobalt complexes galactose ligands prodrug synthesis |
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