Synthesis and biological evaluation of 1,2,4-oxadiazole linked 1,3,4-oxadiazole derivatives as tubulin binding agents |
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| Authors: | Ravikumar Polothi Gajendra Sinh B Raolji Venkata Sastry Kuchibhotla Kalidasu Sheelam Balaaraju Tuniki Prashanth Thodupunuri |
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| Institution: | 1. Department of Chemistry, JNT University, Hyderabad, Telangana, India;2. GVK Biosciences Private Limited, Hyderabad, Telangana, India;3. GVK Biosciences Private Limited, Hyderabad, Telangana, India;4. C.M.R. College of Pharmacy, Hyderabad, Telangana, India;5. Department of Chemistry, School of Science, Gitam University, Hyderabad, Telangana, India;6. Organic and Bimolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India |
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| Abstract: | As an aspect of our ongoing research in search of new anticancer agents, a series of novel analogs of 1,3,4-oxadiazole embedded with 1,2,4-oxadiazole moieties (11a–j) were synthesized. The structure of the final compounds was confirmed by 1H NMR, 13CNMR and mass spectroscopic techniques and evaluated for their in vitro anticancer activity against three human cancer cell lines (lung, breast). Among the synthesized compounds, 11?b, 11?g, 11?h, and 11i showed potent anticancer activity with IC50 values within the range of 0.34?±?0.025 to 2.45?±?0.23?μM against three human cancer cell lines. Further, these compounds (11a–j) were investigated for molecular docking studies. Among them, compound 11?h showed strong binding affinity on binding sites of target protein EGFR (PDB ID: 4hjo) with highest docking score (-7.028). It revealed that 11?h was a strong tubulin binding agent. |
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| Keywords: | Raltegravir Zibotentan phidianidines A B anticancer activity |
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