|
|||||
|
|
An NMR study of the interaction between Melanin Free Acid and Mn ions as a model to mimic the enhanced proton relaxation rates in melanotic melanoma |
|
| Authors: | Silvio Aime Mauro Fasano Enzo Terreno Corrado Sarzanini and Edoardo Mentasti |
| Institution: | a Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, Università degli Studi di Torino, Via P. Giuria 7, 10125, Torino, Italy b Dipartimento di Chimica Analitica, Università degli Studi di Torino, Via P. Guiria 5, 10125, Torino, Italy |
| Abstract: | The interaction of a soluble Melanin Free Acid (MFA) from Sepia melanin with Mn2+ ions is investigated by measuring the proton water relaxation rates. The similarity between MFA and the parent melanin is assessed by means of their high resolution 13C cross polarization magic angle spinning NMR spectra. The observed marked increase in longitudinal proton relaxation rates and the characteristic 1/T1 NMRD profile are associated to the formation of a macromolecular metal complex. The presence of similar paramagnetic species is expected to cause the high contrast shown by melanotic tissues in MRI. |
| Keywords: | Author Keywords: CPMAS Melanin Melanoma MRI NMRD PRE |
| 本文献已被 ScienceDirect 等数据库收录！ | |