Synthesis of Prolinal Dithioacetals as Catalysts for the Highly Stereoselective Michael Addition of Ketones and Aldehydes to beta-Nitrostyrenes |
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| Authors: | Mandal Tanmay Zhao Cong-Gui |
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| Institution: | Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA |
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| Abstract: | Catalytic highly enantioselective (up to >99% ee) and diastereoselective (up to 99% de) direct Michael addition of ketones and aldehydes to β-nitrostyrenes have been achieved with readily accessible and highly tunable prolinal dithioacetal catalysts. |
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| Keywords: | Asymmetric Dithioacetals β-Nitrostyrene N-Boc-prolinal Proline Enantioselective Diastereoselective |
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