Water-soluble chiral monosulfonamide-cyclohexane-1,2-diamine-RhCp complex and its application in the asymmetric transfer hydrogenation (ATH) of ketones |
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| Authors: | Norma A Cortez |
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| Institution: | Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Apartado Postal 1166, Tijuana, B.C. 22500, Mexico |
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| Abstract: | Monosulfonamide ligands with heteroatom/heterocyclic systems were derived from trans-(1R,2R)-cyclohexane-1,2-diamine and complexed with Ru(benzene)Cl2]2, Cp∗RhCl2]2 in situ and used in the ATH of aromatic ketones with aqueous sodium formate as the hydrogen source. The chiral secondary alcohols were obtained with >93% enantioselectivity and >89% yield. Reduction in water was faster than in isopropanol/KOH. Addition of surfactants showed little or no effects. |
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| Keywords: | Monosulfonamide ligands RhCp&lowast complex Asymmetric transfer hydrogenation Ketones |
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