Asymmetric construction of quaternary carbon stereocenter by Pd-hemilabile ligand-catalyzed allylic substitution |
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Authors: | Yoshimasa Fukuda Toyohiko Aoyama |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan |
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Abstract: | The catalyst comprised [PdCl(η3-C3H5)]2 and a simple chiral hemilabile ferrocene ligand, 1′,2-bis(diphenylphosphinoethyl)ferrocenyl alcohol, provides synthetically acceptable results for an enantioselective Pd-catalyzed allylic alkylation of cyclohexanone derivatives bearing an electron-withdrawing group at the α-position to form the quaternary carbon with up to 90% enantioselectivity under mild reaction conditions. |
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Keywords: | Asymmetric quaternary carbon Chiral hemilabile ligand Enantioselective Pd-catalyzed allylic substitution |
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