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Synthetic studies on neomarinone: practical and efficient stereoselective synthesis of the side chain |
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| Authors: | Rosa M. Suá rez,José Pé rez Sestelo |
| Affiliation: | Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain |
| Abstract: | A practical and efficient stereoselective synthesis of the side chain of neomarinone is reported. The synthesis was achieved in six steps (41% overall yield) from 2-methyl-2-cyclohexenone. The key step is a novel stereoselective 1,4-conjugate addition/enolate alkylation by an epoxide-opening reaction. |
| Keywords: | Natural product synthesis 1,4-Addition reactions Enolate alkylation reactions Stereoselective synthesis |
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