Enzymatic kinetic resolution of racemic 4-tetrahydropyranols by Candida rugosa lipase |
| |
| Authors: | JS Yadav BVSubba Reddy B Padmavani Ch Venugopal ABhaskar Rao |
| |
| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
| Abstract: | Enzymatic kinetic resolution of (±)-hydroxytetrahydropyrans has been achieved for the first time by means of lipase-mediated transesterification to afford optically active (2S,4R)-tetrahydropyranyl acetates and (2R,4S)-tetrahydropyranols in excellent yields with high enantioselectivity. Absolute configurations of the tetrahydropyranyl acetates were assigned as (S) by chemical correlation. |
| |
| Keywords: | Kinetic resolution Lipase Tetrahydropyranols |
| 本文献已被 ScienceDirect 等数据库收录！ |
