The fragmentation reaction of 16R-bromopregnane-3S,20S-diol |
| |
| Authors: | Jing-Rong Lin Qi-Hai Xu Wei-Sheng Tian |
| |
| Affiliation: | a Department of Chemistry, College of Life Sciences and Environment, Shanghai Normal University, Shanghai 200234, China
b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China |
| |
| Abstract: | 16R-Bromopregnane-3S,20S-diol reacted with potassium t-butoxide to afford androst-16-en-3S-ol in a moderate yield via fragmentation reaction. The latter is a key intermediate for the synthesis of 5α-androst-16-en-3-one, as boar sex pheromone, and other steroidal drugs. In addition, 16R,20S-epoxypregnane-3S-ol was also obtained as a major product by changing the reaction solvent. |
| |
| Keywords: | Tigogenin Pregnanetriol 16R-Bromopregnane-3S,20S-diol Fragmentation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
