Synthesis and structural studies of some copper-benzoate complexes |
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| Authors: | Sujata Kashyap Udai P Singh A K Singh Pravindra Kumar Shivendra Pratap Singh |
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| Institution: | 1. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247 667, India
2. Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247 667, India
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| Abstract: | The reaction of CuCl2·2H2O with 3,5-diisopropylpyrazole (PziPr2H) in the presence of sodium parafluorobenzoate (Na-p-FBz) resulted in the formation of an oxo-chloro-bridged tetranuclear complex Cu4(PziPr2H)4(μ-O)(μ-Cl)6] 1, whereas the reaction of Cu(NO3)2·3H2O with PziPr2H in the presence of different benzoates gave Cu(PziPr2H)2(μ-OCH3)]2(NO3)2 2, Cu(PziPr2H)3(NO3)(p-ClBz)]·CH3CN 3, Cu(p-CH3Bz)2(PziPr2H)]2·2CH3CN 4, Cu(p-OCH3Bz)2(CH3CN)]2·4CH3CN 5 and Cu(p-CNBz)(CH3CN)]2 6. Single-crystal X-ray diffraction studies confirmed these formulations. DNA binding studies for these complexes were performed by means of UV-visible absorption titration and viscosity measurements. Gel electrophoresis studies showed that hydroxyl radicals are involved in DNA cleavage in the presence of the complexes. |
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