One-pot,three component synthesis of novel 5H-[1,3,4]thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives by microwave irradiation |
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| Authors: | Bing Zhao Yu Xu Qi-Gang Deng Zhuo Liu Li-Yan Wang Yan Gao |
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| Institution: | 1. Chemistry and Chemical Engineering Institute, Qiqihar University, Qiqihar 161006, China;2. School of Chemical Engineering, University of Science and Technology LiaoNing, Anshan 114051, China |
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| Abstract: | An efficient one-pot synthetic method for the highly substituted 5H-1,3,4]thiadiazolo3,2-a]pyrimidine-6-carboxylate derivatives has been accomplished via a microwave irradiation of MCRs of various aldehydes, 2-aminothiadiazole, and acetoacetate without any catalyst in acetic acid. This approach provides a convenient one pot method for the synthesis of 5H-1,3,4]thiadiazolo3,2-a]pyrimidine-6-carboxylate derivatives. |
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| Keywords: | One-pot synthesis Three component 5H-[1 3 4]Thiadiazolo[3 2-a]pyrimidine-6-carboxylate Microwave irradiation |
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