An efficient synthesis of 3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline,a promising radioprotector for cancer radiotherapy |
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| Authors: | Haitao Wu Vincent Coble Olga Vasalatiy Rolf E Swenson Murali C Krishna James B Mitchell |
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| Institution: | 1. Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States;2. Radiation Biology Branch, Center for Cancer Research, National Cancer Institute. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States |
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| Abstract: | Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed. |
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| Keywords: | Nitroxide Redox Radioprotector MRI EPRI |
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