Two novel polycyclic spiro lignans from Gymnotheca involucrata |
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| Authors: | Shi-Ji Xiao Xin-Xiang Lei Bing Xia Dan-Qing Xu Hong-Ping Xiao Hong-Xi Xu Fang Chen Li-Sheng Ding Yan Zhou |
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| Affiliation: | 1. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;2. Pharmacy School, Zunyi Medical College, Zunyi 563000, PR China;3. Wenzhou University, Wenzhou 325035, PR China;4. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;5. College of Life Science, Sichuan University, Chengdu 610064, PR China |
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| Abstract: | ![]()
Two novel lignans, gymnothespirolignans A (1) and B (2), possessing a rare polycyclic spiro skeleton, were isolated from the endemic plant of Gymnotheca involucrata Pei. Their structures were determined by spectroscopic evidences and the absolute configurations were confirmed by single crystal X-ray diffraction analysis. Compounds 1 and 2 showed promising antiviral activities against RSV with an IC50 value of 31.87 and 17.51 μM, respectively. |
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| Keywords: | Gymnotheca involucrata Lignan Absolute stereochemistry |
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