Expedient BINOL derivative arylations |
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| Authors: | Mathieu Albini,Catherine Taillier,Vincent Dalla,Jé rô me Blanchet,Jacques Rouden |
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| Affiliation: | 1. Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6 boulevard du Maréchal Juin, 14050 Caen, France;2. Unité de Recherche en Chimie Organique et Macromoléculaire, Faculté des Sciences et Techniques de l’Université du Havre, 25 rue Philippe Lebon, BP 540, 76058 Le Havre Cedex, France |
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| Abstract: | ![]()
A dramatic improvement of our previous methodology based on a Suzuki–Miyaura cross-coupling to access 3,3′-disubstituted H8-BINOLs using microwave heating is reported herein. These new conditions represent a large gain in term of atom-economy, reaction time, catalyst loading, and excess of reagents employed. |
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| Keywords: | Suzuki coupling Palladium BINOL Microwave Arylation |
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