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An efficient,one-pot synthesis of N-isatinylmethylthioacetic acid and its derivatives as potential anticancer agents |
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| Authors: | Lev Yu. Ukhin Arina R. Akopova Anatolii S. Morkovnik Kirill Yu. Suponitzky Evgenii N. Shepelenko Alexander V. Bicherov Leonid D. Popov |
| Affiliation: | 1. Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don 344090, Russia;2. Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia;3. Southern Scientific Center, Russian Academy of Sciences, Rostov-on-Don 344006, Russia;4. Southern Federal University, Faculty of Chemistry, Rostov-on-Don 344090, Russia |
| Abstract: | A convenient, one-pot synthesis of N-isatinylmethylthioacetic acid and several of its derivatives, as potential anticancer agents, by reactions of N-(hydroxymethyl)isatins with Bunte salts in TFA is described. The reactions involve attack of these salts on the S(II) atom by C-electrophilic species generated from hydroxy derivatives. |
| Keywords: | VYWPPRLJNVHPEU-UHFFFAOYSA-N OTKIGRVGCPCASR-UHFFFAOYSA-N PQXSDOKSKOPVJQ-UHFFFAOYSA-N |
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