A concise approach to CF3-containing furan-3-ones, (bis)pyrazoles from novel fluorinated building blocks based on 2,3-butanedione |
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| Authors: | Denis N Bazhin Dmitry L Chizhov Gerd-Volker Röschenthaler Yulia S Kudyakova Yanina V Burgart Pavel A Slepukhin Victor I Saloutin Valery N Charushin |
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| Institution: | 1. I.Ya. Postovsky Institute of Organic Synthesis, The Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy Str., 620990 Ekaterinburg, Russian Federation;2. School of Engineering and Science, Jacobs University Bremen, 28759 Bremen, Germany;3. Ural Federal University, Ekaterinburg, Russian Federation |
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| Abstract: | 1,1,1-Trifluoro-4,5,5-trimethoxyhex-3-en-2-one and lithium (2Z)-1,1,1-trifluoro-5,5-dialkoxy-4-oxohex-2-en-2-olate were synthesized for the first time via direct trifluoroacetylation of 2,3-butanedione acetal derivatives. A simple and effective approach to acetal or acyl substituted CF3-pyrazoles, 5,5′-bis(trifluoromethyl)-3,3′-bipyrazole, and, to 5-trifluoromethylfuran-3-ones is presented. |
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| Keywords: | IDHSXAPSNQYGSO-ALCCZGGFSA-N DZMZRYIOPYDRMG-YHSAGPEESA-M TWUFRSLEKGUYDM-PHZXCRFESA-M ZUVOUMSQKNBLGX-UHFFFAOYSA-N WBZITEZZKOAGQB-UHFFFAOYSA-N QOIBLHJWEPABQH-VURMDHGXSA-N OUSKCOIEPPZGJA-UHFFFAOYSA-N ZCINKELYVYKGIL-UHFFFAOYSA-N FGQGPIIKARTBRR-WMXOHYAGSA-N QKZGEOBDOPUFGG-UHFFFAOYSA-N |
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