Stereoselective total synthesis of oplopandiol,oploxyne A,and oploxyne B |
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| Authors: | BV Subba Reddy R Nageshwar RaoB Kumaraswamy JS Yadav |
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| Institution: | Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India |
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| Abstract: | A stereoselective total synthesis of oplopandiol, oploxyne A, and (−)-oploxyne B is described. The key reactions include Sharpless asymmetric epoxidation, d-proline catalyzed aminoxylation, Cadiot–Chodkiewicz cross-coupling reaction, m-CPBA induced substrate-controlled stereoselective epoxidation, and Lewis acid catalyzed stereo- and regioselective ring-opening of epoxide. |
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| Keywords: | Organocatalyzed aminoxylation Sharpless asymmetric epoxidation Ene-diynes Cadiot&ndash Chodkiewicz cross-coupling reaction |
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