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Electrophile-driven copper-catalyzed one-pot synthesis of 3-halogen quinoline derivatives |
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| Authors: | Jie Cheng Hong Zhai Jun Bai Jun Tang Ling Lv Bei Sun |
| Institution: | 1. Office of Scientific Research, Anhui Provincial Institute for Food and Drug Control, Hefei 230022, China;2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China |
| Abstract: | A convenient and regioselective one-pot synthesis of 3-chloride or 3-bromide quinoline derivatives was achieved through a Grignard addition reaction by alkynyl Grignard regent to o-trifluoroacetyl aniline and a Cu(II)-catalyzed cyclization–halogenation tandem reaction with aqueous HCl or HBr as electrophilic reagent. |
| Keywords: | GBAGYKNRWWPLLD-UHFFFAOYSA-N AHURFDBRXAZEFK-UHFFFAOYSA-N NFOPILKGLNQHQI-UHFFFAOYSA-N CGNMAWGLGRPYOD-UHFFFAOYSA-N OAFYCYQBXPHNBY-UHFFFAOYSA-N BOJQCXUOVMOADW-UHFFFAOYSA-N RAJHHECFEIQZHO-UHFFFAOYSA-N ZVCMHQQFNNCZGB-UHFFFAOYSA-N WCOJREYSWPTJAG-UHFFFAOYSA-N MPCWBUZSUZBFNI-UHFFFAOYSA-N QYVHMCBEHHYDJO-UHFFFAOYSA-N ISRMCGNCJYBKKG-UHFFFAOYSA-N FRDCRBGJJKUOEW-UHFFFAOYSA-N PKOUQRSJLLXDEN-UHFFFAOYSA-N WPHUWEOHGOQJSC-UHFFFAOYSA-N QYQOZVNVSJFWAM-UHFFFAOYSA-N KEKNIFPBQKXLMM-UHFFFAOYSA-N WWGCZFPWGRUBGZ-UHFFFAOYSA-N LIEHJMIGOGBZDT-UHFFFAOYSA-N HCNZAAVGLGDUMO-UHFFFAOYSA-N VTLCCRSEJLGBIC-UHFFFAOYSA-N |
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