A novel one pot multi-component strategy for facile synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones |
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| Authors: | M.M. Mane D.M. Pore |
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| Affiliation: | Department of Chemistry, Shivaji University, Kolhapur 416 004, India |
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| Abstract: | ![]()
We have disclosed an efficient, one pot, novel multi-component approach for the synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones from aldehyde, hydrazine hydrate, and trimethylsilyl isothiocyanate (TMSNCS) in the presence of catalytic amount of sulfamic acid. High yields, easy work-up procedure, no chromatographic separation, and novelty in multi-component strategy are the main merits of the present strategy. |
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| Keywords: | Multi-component Aldehyde Hydrazine hydrate Trimethylsilyl isothiocyanate 5-Aryl-[1,2,4]triazolidine-3-thiones |
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