Cu(OTf)2-promoted efficient synthetic route towards glycospiro-pyrrolo[2,1-a]isoquinolines |
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| Authors: | Piyali Deb Barman Ishita SanyalSukhendu B. Mandal Asish Kumar Banerjee |
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| Affiliation: | Department of Chemistry, CSIR-Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India |
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| Abstract: | A simple, convenient and efficient protocol for the construction of an array of glycospiro-pyrroloisoquinolines using isoquinolinium ylide and a carbohydrate-derived exocyclic olefin in the presence of Cu(OTf)2–Et3N catalytic system is described. Isoquinoline and alkylbromoacetates/2-bromoacetophenones were employed to generate the azomethine ylides in the presence of Et3N in refluxing toluene and subsequent exposure to the olefin led to the desired isoquinoline derivatives. |
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| Keywords: | Azomethine ylides Cycloaddition reactions Copper triflate Synthesis Glycospiropyrrolo[2,1-a]isoquinolines |
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