A new route to the versatile synthesis of thiopyrano[2,3-b:6,5-b′]diindoles via 2-(alkylthio)-indole-3-carbaldehydes |
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Authors: | Mukund Jha Michael EdmundsKate-lyn Lund Ashley Ryan |
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Institution: | Department of Biology and Chemistry, Nipissing University, North Bay, ON P1B 8L7, Canada |
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Abstract: | A versatile synthesis of symmetrically and unsymmetrically substituted thiopyrano2,3-b:6,5-b′]diindoles has been developed by the condensation of 2-(alkylthio)-indole-3-carbaldehydes with indoline-2-thiones in the presence of catalytic amount of ethylenediamine diacetate (EDDA). The EDDA mediated condensation leads to a spontaneous cyclization followed by aromatization to form thiopyrano2,3-b:6,5-b′]diindoles in quantitative yields. |
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Keywords: | Indole Heteroaromatic Formylation Sulfide Cyclization |
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