Hydrated ferric sulfate catalyzed synthesis of 5,6-unsubstituted 1,4-dihydropyridines using three-component reaction |
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| Authors: | Kobirul Islam Deb K Das Abu T Khan |
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| Institution: | 1. Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India;2. Aliah University, DN-18, 8th Floor, Sector V, Salt Lake, Kolkata 700 091, West Bengal, India |
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| Abstract: | A wide variety of 5,6-unsubstituted 1,4-dihydropyridines derivatives (4a–q) were synthesized through a one-pot three-component reaction from α,β-unsaturated aldehydes, amines, and 1,3-diketones at room temperature using hydrated ferric sulfate as a Lewis acid catalyst. The key features of the present protocol are mild and simple reaction procedure, good to excellent yields, and use of inexpensive, recyclable, and environmentally benign catalyst. |
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| Keywords: | 5 6-Unsubstituted 1 4-dihydropyridines α β-Unsaturated aldehydes Amines 1 3-Diketones Hydrated ferric sulfate [Fe2(SO4)3· xH2O] |
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