| 两种新颖的席夫碱与DNA作用的光谱研究 |
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| 引用本文： | 蒲小华,张新利,邹立伟,高虎军.两种新颖的席夫碱与DNA作用的光谱研究[J].光谱实验室,2011,28(2):826-831. |
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| 作者姓名： | 蒲小华 张新利 邹立伟 高虎军 |
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| 作者单位： | 宝鸡文理学院化学化工系,陕西省宝鸡市高新大道1号,721013 |
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| 基金项目： | 植物化学陕西省重点实验室(宝鸡文理学院)资助项目 |
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| 摘 要： | 采用紫外-可见光谱法、荧光光谱法,研究了两种新颖的席夫碱3-溴-5-氯水杨醛缩邻氯苯胺（BCSC）、3-溴-5-氯水杨醛缩对甲基苯胺（BCST）与DNA作用模式,研究表明两种化合物与CT-DNA作用紫外-可见光谱出现减色效应,随着CT-DNA的加入,化合物的荧光强度减弱,同时进行了KI对其荧光的猝灭实验,所有结果显示两种化合物与CT-DNA以嵌入模式结合。
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| 关 键 词： | 席夫碱化合物 CT-DNA 紫外-可见光谱法 荧光光谱法 |
Interaction of Two Novel Schiff Base with DNA by Spectroscopy |
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| PU Xiao-Hua,ZHANG Xin-Li,ZOU Li-Wei,GAO Hu-Jun.Interaction of Two Novel Schiff Base with DNA by Spectroscopy[J].Chinese Journal of Spectroscopy Laboratory,2011,28(2):826-831. |
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| Authors: | PU Xiao-Hua ZHANG Xin-Li ZOU Li-Wei GAO Hu-Jun |
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| Institution: | PU Xiao-Hua ZHANG Xin-Li ZOU Li-Wei GAO Hu-Jun(Department of Chemistry and Chemical Engineering,Baoji University of Arts and Sciences,Baoji,Shaanxi 721013,P.R.China) |
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| Abstract: | The modes of the interaction of two novel Schiff base for BCSC and BCST with CT-DNA were studied by UV-Vis and fluorescence spectrometry.Experimental data indicated that the binding of the two compounds with CT-DNA would cause hypochromic effect in UV-Vis spectra,and the fluorescence intensity of compounds decreased with the addition of CT-DNA;meanwhile the quenching for the compounds with CT-DNA by KI were also studied.The results showed that the interactive model between the compounds and CT-DNA was an in... |
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| Keywords: | CT-DNA |
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