Studies on the syntheses of heterocyclic compounds—DXLV : An alternative synthesis of the protoberberine ring system |
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| Authors: | T. Kametani T. Kato K. Fukumoto |
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| Affiliation: | Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan |
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| Abstract: | The reaction of 3,4-dihydro-6,7-dimethoxyisoquinoline (11) with 1-bromobenzocyclobutene (10) gave, in one step, 2,3-dimethoxyprotoberberinium bromide (15), which was easily converted into the tetrahydroprotoberberine (16). |
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