1.Department of Analytical Chemistry,China Pharmaceutical University,Nanjing,China;2.Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education,China Pharmaceutical University,Nanjing,China;3.Department of Applied Linguistics,University of Warwick,Coventry,UK;4.School of Pharmaceutical Sciences,Taishan Medical University,Tai’an,People’s Republic of China
Abstract:
This review (with 144 refs.) focuses on the recent advances in the preparation and application of magnetic micro/nanoparticles. Specifically, it covers (a) methods for preparation (such as by coprecipitation, pyrolysis, hydrothermal, solvothermal, sol-gel, micro-emulsion, sonochemical, medium dispersing or emulsion polymerization methods), and (b) applications such as magnetic resonance imaging, magnetic separation of biomolecules (nucleic acids; proteins; cells), separation of metal ions and organic analytes, immobilization of enzymes, biological detection, magnetic catalysis and water treatment. Finally, the existing challenges and possible trends in the field are addressed.
Graphical abstract This review focuses on the recent advances in the preparation and application of magnetic micro/nano particles. Finally, the existed problems and possible trends in the field were discussed. a: Fe3O4@SiO2-PVAm: polyvinyl amine-coated Fe3O4@SiO2 b: CTS/MMT-Fe3O4 microsphere: chitosan/montmorillonite-Fe3O4 microsphere c: MTAMs: magnetic targeted antibiotic microspheres d: SM: the code of iron oxide-silica composite microspheres e: PSt: poly styrene f: gamma-PGA- PLA: poly(gamma-glutamic acid) and poly(lactide) g: poly(-MMA–DVB–GMA) microspheres: poly(methylmethacrylate–divinylbenzene–glycidylmethacrylate) microspheres h: AEAPS: N-(2-aminoethyl)-3-aminopropyltrimethoxysilane
