Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa |
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| Authors: | Sakornrat Thorroad Prateep Worawittayanont Nisachon Khunnawutmanotham Nitirat Chimnoi Apiwan Jumruksa Somsak Ruchirawat Nopporn Thasana |
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| Affiliation: | 1. Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Laksi, Bangkok 10210, Thailand;2. Program on Chemical Biology, Chulabhorn Graduate Institute, Laksi, Bangkok 10210, Thailand;3. Laboratory of Organic Synthesis, Chulabhorn Research Institute, Laksi, Bangkok 10210, Thailand;4. Laboratory of Natural Products, Chulabhorn Research Institute, Laksi, Bangkok 10210, Thailand;5. Center of Excellence on Environmental Health and Toxicology, Commission on Higher Educaton (CHE), Ministry of Education, Bangkok, Thailand |
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| Abstract: | Eleven Lycopodium alkaloids with lycodine-type, lycopodine-type, and fawcettimine-related skeletons were isolated from the whole plants of Huperzia carinata (Desv. Ex. Poir.) Trevis and Huperzia squarrosa (G. Forst) Trevis (Huperziaceae). Among them, 8,15-dihydrohuperzine A (2), lycocarinatine A (3), and lycoposerramine U N-oxide (11) are new compounds. The structures of these new alkaloids were elucidated on the basis of 2D NMR correlations. Some of these isolated alkaloids were assayed for acetylcholinesterase (AChE) inhibitory activity. |
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| Keywords: | Huperziaceae Huperzia carinata Huperzia squarrosa Lycopodium alkaloid Acetylcholine esterase |
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