Reactions of enaminones and related compounds with N,N-dimethylacetamide dimethyl acetal. A simple one-pot metal-free synthesis of polysubstituted benzene derivatives |
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| Authors: | Benjamin Prek,Jure Bezen&scaron ek,Marta Kasunič,Uro&scaron Gro&scaron elj,Jurij Svete,Branko Stanovnik |
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| Affiliation: | 1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ašker?eva 5, PO Box 537, SI-1000 Ljubljana, Slovenia;2. EN-FIST Centre of Excellence, Dunajska 156, SI-1000 Ljubljana, Slovenia |
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| Abstract: | ![]()
Herein a simple one-pot metal-free synthesis of alkyl-, aryl-, heteroaryl- and alkoxycarbonyl substituted 1,3-bis(dimethylamino)benzene derivatives is described. The products were prepared from the corresponding methyl ketones or compounds with an α-methylene group in regard to the carbonyl group, using N,N-dimethylacetamide dimethyl acetal (DMADMA) as the reagent. |
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| Keywords: | Methyl ketones 1,3-Dicarbonyl compounds Enaminones Polysubstituted benzene derivatives Cyclocondensations Microwave assisted reactions |
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