Highly diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones via catalyst-free cyclopropanation using ethyl diazoacetate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Highly diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones via catalyst-free cyclopropanation using ethyl diazoacetate

Authors:	Ram Awatar Maurya Chada Narsimha Reddy Geeta Sai Mani Jeevak Sopanrao Kapure Praveen Reddy Adiyala Jagadeesh Babu Nanubolu Kiran Kumar Singarapu Ahmed Kamal

Affiliation:	1. Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, AP, India;2. Centre for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India;3. Centre for Nuclear Magnetic Resonance, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India

Abstract:	Substituted 3-methyleneindolin-2-ones were efficiently cyclopropanated with ethyl diazoacetate to yield spiro[cyclopropane-1,3′-indolin]-2′-ones in a catalyst-free and highly diastereoselective reaction in a mixture of ethanol–acetonitrile (1:1 v/v) as solvent.

Keywords:	Spiro compounds Ethyl diazoacetate Cyclopropanation Stereoselective synthesis Indolin-2-one
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