Synthesis of 4,5-disubstituted-3-deoxy-d-manno-octulosonic acid (Kdo) derivatives |
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| Authors: | Ruiqin Yi Atsushi Ogaki Mayumi Fukunaga Hiromitsu Nakajima Tsuyoshi Ichiyanagi |
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| Institution: | 1. The United Graduate School of Agricultural Sciences, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan;2. Dept of Life and Food Sciences, Faculty of Agriculture, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan |
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| Abstract: | In this study, a new synthetic approach to 4,5-branched Kdo trisaccharides based on the common acceptor Kdo(α2-4)Kdo was developed. The synthesis of three types of 4,5-branched trisaccharides, Hep(α1-5)Kdo(α2-4)]Kdo, Man(α1-5)Kdo(α2-4)]Kdo, and GalNAc(α1-5)Kdo(α2-4)]Kdo, was achieved in good yield and high α-selectivity. |
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| Keywords: | 3-Deoxy-d-manno-2-octulosonic acid Lipopolysaccharide Lipooligosaccharide 4 5-Branched structure Inner-core oligosaccharide |
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