Titanium promoted reduction of imines with Grignards,silanes, and zinc: identification of a new mechanism with silanes |
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Authors: | Akshai Kumar Arun Kumar PandiakumarAG Samuelson |
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Institution: | Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India |
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Abstract: | Aldimines react with reducing agents, such as Grignards, phenylsilane or zinc in the presence of titanium(IV) isopropoxide to form amines and reductively coupled imines (diamines). Using deuterium labeled reagents, the mechanism of reduction to form amines is described. Reducing agents, such as the Grignard and zinc result in the formation of low valent titanium (LVT), which in turn reduces the imine. On the other hand, phenylsilane reacts by a distinctly different mechanism and where a hydrogen atom from silicon is directly transferred to the titanium coordinated imine. |
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Keywords: | Deuterium labeling Low valent titanium Grignard Phenylsilane Zinc |
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