The Lewis acid-catalyzed [3+1+1] cycloaddition of azomethine ylides with isocyanides |
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| Authors: | Takahiro Soeta Yoshiaki Miyamoto Shuhei FujinamiYutaka Ukaji |
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| Institution: | Division of Material Chemistry, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan |
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| Abstract: | A Lewis acid-catalyzed 3+1+1] cycloaddition reaction between aliphatic isocyanides and azomethine ylides generated in situ from aziridines, leading to pyrrolidine derivatives, has been developed. This reaction proceeds smoothly under mild conditions and can also be modified by employing aromatic isocyanides to generate four-membered heterocycles, azetidines, through a 3+1] cycloaddition reaction. |
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| Keywords: | Isocyanide Azomethine ylide Aziridine [3+1+1] Cycloaddition |
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