4,5-Dicyanoimidazole-promoted synthesis of dinucleoside polyphosphates and their analogs |
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Authors: | Qi Sun Shan-Shan Gong Si Liu Jian Sun Guo-Dong Liu Cha Ma |
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Institution: | 1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang, Jiangxi 330013, PR China;2. High Level Engineering Research Center of Biopharmaceutical Molecules and Diagnostic Apparatuses, Jiangxi Provincial Colleges and Universities, Nanchang, Jiangxi 330013, PR China |
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Abstract: | A general and efficient P(V)–N activation method for the preparation of symmetrical and asymmetrical dinucleoside polyphosphates (NpnN′s, n=2–4) and P2,P3-CX2-dinucleoside tetraphosphates (X=H, F, and Cl) has been established. Twenty-two dinucleoside polyphosphates and their phosphonate analogs were synthesized from nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator in good to high yields. |
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Keywords: | Dinucleoside diphosphate Dinucleoside triphosphate Dinucleoside tetraphosphate Phosphoropiperidate 4 5-Dicyanoimidazole |
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