Micropeptins from Microcystis sp. collected in Kabul Reservoir,Israel |
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| Authors: | Tanja Thorskov Bladt Sivan Kalifa-Aviv Thomas Ostenfeld Larsen Shmuel Carmeli |
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| Institution: | 1. Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs. Lyngby, Denmark;2. Raymond and Beverly Sackler School of Chemistry and Faculty of Exact Sciences, Tel Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel |
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| Abstract: | Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase. |
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| Keywords: | Cyanobacteria Microcystis Micropeptins Protease inhibitors Natural products |
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