|
|||||
|
|
One-pot synthesis of trifluoromethylated phthalans via intramolecular cyclization from 2-alkynylbenzaldehydes |
|
| Authors: | Lijun Xu Haizhen Jiang Jian Hao Gang Zhao |
| Affiliation: | 1. Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China;2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China |
| Abstract: | An efficient tandem addition/cyclization procedure for the synthesis of trifluoromethylated phthalans under mild conditions was developed. This procedure involves tetrabutylammonium fluoride (TBAF)-promoted addition of Ruppert–Prakash reagent (TMSCF3) to 2-alkynylbenzaldehyde to give 2-alkynylbenzylicalcohols, which would then undergo base-catalyzed selective 5-exo-dig cyclization to furnish the corresponding products. |
| Keywords: | Trifluoromethylation Ruppert&ndash Prakash reagent Intramolecular cyclization Tetrabutylammonium fluoride 2-Alkynylbenzaldehyde |
| 本文献已被 ScienceDirect 等数据库收录！ | |