Pd-catalyzed Negishi coupling of pyrazole triflates with alkyl zinc halides |
| |
| Authors: | Ting Zhang Xiaodi GaoHarold B Wood |
| |
| Institution: | a Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA
b Merck Summer Research Intern, University of Michigan, Ann Arbor, MI, USA |
| |
| Abstract: | A mild, functional group tolerant palladium-catalyzed Negishi coupling of pyrazole triflates and nonaflates with alkyl, benzyl, and aryl zinc halides has been developed. It allows quick access to 3-substituted pyrazole analogs at late stage via common synthetic intermediates. |
| |
| Keywords: | Negishi coupling Cross-coupling Palladium catalysis Pyrazole triflates Organozinc reagents Analog synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
