超分子作用构筑具有高光学不对称性的表面等离子纳米粒子手性组装体

《Science》杂志最近刊发了吉林大学刘堃团队关于手性纳米材料研究的重要进展: 通过超分子作用诱导金纳米棒与人胰岛淀粉样多肽之间共组装, 构筑具有类似于手性液晶结构的纳米螺旋超结构. 与单独的金纳米棒相比, 长程有序的纳米螺旋结构的手性各向异性因子(g-factor)提高了4600倍, 高达0.12. 该工作在液晶与手性无机纳米结构间建立了联系, 为构筑有机-无机光学活性结构提供了统一的设计原则, 并为淀粉样类疾病药物在复杂生物介质中的筛选开发了新方法.

Supramolecular Interactions Induced Chiral Assembly of Plasmonic Nanoparticles with Enhanced Optical Asymmetry

Science has recently reported the important progress of chiral nanomaterials achieved by LIU Kun’s group from Jilin University and coworkers. Supramolecular interactions of gold nanorods（NRs） with human islet amyloid peptides catalyze their assembly into metallic superstructures with unusually high cholesteric order. Contrary to current theories， the transition from individual NRs to long straight helices leads to increase of g-factor（up to 0.12） by 4600 times. This work establishes the link between the liquid crystals and chiral inorganic nanostructures； provides unifying design principles for organic and inorganic optically active media and opens new modalities for drug discovery for amyloid diseases.