基于激光介导富集的表面增强拉曼分析

基于具有优异表面增强拉曼散射(SERS)性能的石墨烯隔离的金纳米晶(GIAN)能够在水-有机相界面自组装, 待测物分子在有机相中的分配系数较大以及GIAN能够通过π?π相互作用与待测物分子结合的优势, 构建了激光介导的待测物分子的高效富集策略, 进而实现了9,10-双苯乙炔基蒽(BPEA)分子的痕量SERS分析. 所构建的新型待测物分子高效富集策略在一定程度上避免了因“咖啡环效应”带来的信号波动, 有望为复杂体系中痕量待测物的SERS分析提供可靠的平台.

Laser-mediated Enrichment Based Surface Enhanced Raman Analysis

Surface enhanced Raman scattering（SERS） technique has extensive application prospects in biochemical analysis and environmental monitoring field owing to its high sensitivity， low background inter- ference， superior anti-photobleaching and anti-photocarbonization capabilities， as well as ability to reflect the inherent molecular fingerprint information of the analyte. Non-target analytes are competitively adsorbed on the surface of the SERS substrate， making the analysis of trace analytes in complex systems extremely challenging. Based on the self-assemble of the graphene-isolated Au nanocrystal（GIAN） with excellent SERS performance at H₂O-Organic phase interface， the large partition coefficient of the analyte in organic phase， and GIAN can combine with the analyte viaπ-π interaction， a laser-mediated highly-efficient analyte enrichment strategy is proposed and trace SERS analysis of 9，10-bis（phenylethynyl）anthracene（BPEA） molecules is eventually realized in this work. The proposed novel analyte enrichment strategy avoids the signal fluctuation caused by the “coffee ring effect” to a certain extent and is expected to provide a reliable platform for SERS analysis of trace analytes in complex systems.