层状水凝胶仿生软骨的制备与性能

采用超声分散、高压加热共融、冷冻-熔融和γ射线辐照交联成型工艺制备层状水凝胶仿生软骨材料, 系统讨论了PVP添加量和辐照剂量对材料的凝胶含量、晶态结构及抗压缩弹性模量的影响, 观察和研究了层状水凝胶的微观结构. 研究结果表明, 随着PVP的质量分数(0-40%)和辐照剂量(0-60 kGy)的增加, 层状水凝胶的凝胶含量呈上升趋势; 其晶态结构在质量分数为20%的PVP和10 kGy辐照剂量下最完善; 其力学性能在质量分数为20%的PVP和20 kGy辐照剂量下最佳; PVP的加入改善了水凝胶的微观形貌, 有利于材料表面润滑性能的提高; 层状水凝胶层间渗透结合, 自然过渡, 形成结构良好的仿生软骨材料.

Preparation and Properties of Two-layer Integrative Hydrogel as Biomimetic Cartilage Replacement Material

Two-layer integrative hydrogels were prepared as biomimetic articular cartilage replacement materials through ultrasonic dispersion, heat-high-pressure, freeze/thawed and radiation technique. The effects of PVP mass fraction and irradiation dose on the gel content, crystallinity structures and elastic compress modulus were investigated. The microstructures of the two-layer integrative hydrogels were also characterized. It was found that the gel content increased with the increase of PVP mass fraction(0—40%) and irradiation dose(0—60 kGy). The crystallinity of PVP-PVA composite hydrogel is the highest under 10 kGy irradiation dose and 20%PVP. Two-layer integrative hydrogel with 20% PVP under 20 kGy irradiation dose showed the highest elastic compress modulus. SEM results show that the surface structures of PVP-PVA composite hydrogels were improved with increasing the PVP mass fraction. SEM results also indicate that the integrative hydrogel showed a good compatibility between top-layer and underlayer. Based on the above results, the two-layer integrative hydrogel showed a promoting prospect as biomimetic cartilage replacement material.