| Synthesis,Crystal Structure and DNA Interaction of N-（Benzimidazol- 2-ylmethyl）-5-chlorosalicylideneimine |
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| 引用本文： | 程建平,林秋月,朱文忠,王云云,咸会朵.Synthesis,Crystal Structure and DNA Interaction of N-（Benzimidazol- 2-ylmethyl）-5-chlorosalicylideneimine[J].结构化学,2009,28(2):235-239. |
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| 作者姓名： | 程建平 林秋月 朱文忠 王云云 咸会朵 |
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| 作者单位： | CHENG Jian-Ping,LIN Qiu-Yue,ZHU Wen-Zhong(Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China;College of Chemical and Life Science,Zhejiang Normal University,Jinhua 321004,China);WANG Yun-Yun,XIAN Hui-Duo(Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China)
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| 摘 要： | The title compound, N-（benzimidazol-2-ylmethyl）-5-chlorosalicylideneimine, has been synthesized and characterized by X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P21/n, with a = 8.3765（2）, b = 18.1398（4）, c = 9.4764（3）А, β= 112.141（2）°, V= 1333.74（6）А^3, Mr = 285.73, Z = 4, Dc = 1.423 g/cm^3, F（000） = 592,/z = 0.285 mm^-1, the final R = 0.0538 and wR = 0.1456 for 1917 observed reflections with I〉2σ-（I）. The fluorescence quenching of the title compound by DNA with Stern-Volmer constant of 2.8×104 M^-1 indicates that it binds to double-stranded DNA in a partial intercalation mode.
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| 关 键 词： | 晶体结构 2-氨基甲基苯并咪唑 5-氯代水杨醛 DNA |
Synthesis,Crystal Structure and DNA Interaction of N-(Benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine |
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| CHENG Jian-Ping,LIN Qiu-Yue,ZHU Wen-Zhong,WANG Yun-Yun,XIAN Hui-Duo.Synthesis,Crystal Structure and DNA Interaction of N-(Benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine[J].Chinese Journal of Structural Chemistry,2009,28(2):235-239. |
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| Authors: | CHENG Jian-Ping LIN Qiu-Yue ZHU Wen-Zhong WANG Yun-Yun XIAN Hui-Duo |
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| Institution: | 1. Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China;College of Chemical and Life Science,Zhejiang Normal University,Jinhua 321004,China
2. Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces,Zhejiang Normal University,Jinhua 321004,China |
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| Abstract: | The title compound, N-(benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine, has been synthesized and characterized by X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P21/n, with a = 8.3765(2), b = 18.1398(4), c = 9.4764(3) A, β = 112.141(2)°, V= 1333.74(6) A3, Mr = 285.73, Z = 4, Dc = 1.423 g/cm3, F(000) = 592, μ= 0.285 mm-1, the final R = 0.0538 and wR = 0.1456 for 1917 observed reflections with I > 2σ(Ⅰ). The fluorescence quenching of the title compound by DNA with Stern-Volmer constant of 2.8×104 M1 indicates that it binds to double-stranded DNA in a partial intercalation mode. |
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| Keywords: | crystal structure 2-aminomethylbenzimidazole 5-chlorosalicylaldehyde DNA |
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