3,4 AND 4',5'-PHOTOCYCLOADDUCTS BETWEEN 4'-METHYLANGELICIN AND THYMINE FROM DNA |
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| Authors: | S Caffieri V Luccmni P Rodighiero G Miolo F Dall'Acqua |
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| Institution: | Department of Pharmaceutical Sciences, University of Padua Padova, Italy;Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C.N.R., Padova;Department of Environmental Sciences, University of Venezia, and Centro Meccanismi Reazioni Organiche del C.N.R., Padova, Italy |
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| Abstract: | Abstract— Two C4-cycloadducts between 4'-methylangelicin and thymine were isolated from the photo-reaction (365 nm) between this furocoumarin and DNA. Their capacity to undergo photoreversion at 254 nm and their spectroscopic and NMR data allowed us to assign furan- and pyrone-side structures, respectively, to these photocompounds. The former adduct has a cis-syn configuration; the latter. which was also isolated from a photoreaction between the furocoumarin and thymine in water-methanol solution, was assigned a cis-anti structure. |
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