A study of photodegradation of quetiapine by the use of LC-MS/MS method |
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Authors: | Robert Skibiński |
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Institution: | (1) The Key Laboratory of Food Science and Safety, Ministry of Education, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, Jiangsu Province, People’s Republic of China |
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Abstract: | Photodegradation of quetiapine under UVC irradiation in methanol solution was investigated and structural elucidation of its
photodegradation products was performed with the use of the reversed phase UHPLC system coupled with accurate mass hybrid
ESI-Q-TOF mass spectrometer. During one run all essential data for the determination of photodegradation kinetics and for
the structural elucidation of the products was collected with the use of auto MS/MS mode. Five degradation products were found
and their masses and formulas were obtained with high accuracy (0.26–5.02 ppm). For all the analyzed compounds, MS/MS fragmentation
spectra were also obtained allowing structural elucidation of the unknown degradation products and indicating photodegradation
pathways of quetiapine. The main photodegradation product was identified as 2-2-4-(5-oxidodibenzob,f]1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]-ethanol
and the photodegradation reaction yields the first-order kinetics with the rate constant k = 0.1094 h−1. |
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Keywords: | |
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